Read An Article A Month

Let’s read an article a month – March 06, 2020

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Snapshot of the first page of the article.

Every month I try to read an open-access article. After reading the article, I share the tittle and associated link with my followers. This is to encourage clinicians to read articles, stay up to date, and continue to grow.

I found an article on Feb 27th, 2020. I spent a few days with it, and now I share it with you.

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained
by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages by Nikita Joshi et al.
 
 Eur Respir J 2020 55:1900646; published ahead of print 2019, doi: 10.1183/13993003.00646-2019 https://erj.ersjournals.com/content/erj/55/1/1900646.full.pdf

This article is well written and easy to follow. I must admit that it is too specialized and technical for my comfort level, but I still enjoyed it.

What this study demonstrates? Many elements were discussed but here is a very simple summary to get you interested:

“Our findings suggest that inhibition of M-CSFR (macrophage colony-stimulating factor receptor) signalling during fibrosis disrupts an essential fibrotic niche that includes monocyte-derived alveolar macrophages and fibroblasts during asbestos-induced fibrosis.” p1

Happy reading!

Farzad Refahi

Let’s read an article a month –Feb. 21, 2020

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Photo of the article’s first page.

Every month I try to read an open access article. After reading the article, I share the tittle and associated link with my followers. This is to encourage clinicians to reads articles, stay up to date and continue to grow.

The article I read on Friday was:

Bilateral hypoglossal nerve stimulation for treatment of adult obstructive sleep apnoea by Peter R. Eastwood et al.

Eur Respir J 2020 55:1901320; published ahead of print 2019, doi:10.1183/13993003.01320-2019 OPEN ACCESS ARTICLE http://erj.ersjournals.com/content/55/1/1901320?etoc

I am not here to endorse this technology or this approach to manage Obstructive Sleep Apnea (OSA). I am learning about it and sharing it with you. It did open my eyes to another approach which apparently has been around for some time. I appreciated the innovations. Compliance with CPAP units, the current gold stands, is low. The authors do mention that, and I have personally witnessed it when I worked for a CPAP company (casually for around 2 years).

I don’t need to express my personal thoughts on this as the authors have done a great job of describing the technology (GEnio system), what’s make it unique, the limitation of the study, and also the opportunities it brings.

It is a small study, n=22, with few participants. There is no control group.

This approach did open up the discussion to devices that deliver bilateral stimulation of hypoglossal nerve, includes minimal incision, and lacks an implanted battery (p10).

What are your thoughts and take on this?

Let’s read an article a month – April 3 2019

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An Article A Month

Every month I try to read an open-access article.  After reading the article, I share the tittle and associated link with my followers.  This is to encourage clinicians to read articles, stay to up to date, and continue to grow.

This morning I read this recent editorial piece on ERS:

The new haemodynamic definition of pulmonary hypertension: evidence prevails, finally!

By Marius M. Hoeper and Marc Humbert.

https://erj.ersjournals.com/content/erj/53/3/1900038.full.pdf

I wanted to review the noninvasive ways of measuring for pulmonary hypertension and came across this useful resource: https://www.123sonography.com/book/352

Happy Reading!

Farzad Refahi
April 3 2019 
https://respiratory.blog/rvsp/

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